Table 1:

Metabolic processes regulated by HNF4α

HNF4α manipulation	Organism	Effect	Reference
Liver-specific HNF4α deletion	Mouse	Disrupted bile acid conjugation	[31, 91]
Liver-specific HNF4α deletion	Mouse	Disrupted blood coagulation homeostasis	[30]
Liver-specific HNF4α deletion	Mouse	Defective ureagenesis	[92]
Liver-specific HNF4α deletion	Mouse	Decreased expression of genes involved in amino acid metabolism	[32]
INS-1 Cell line with dominant negative mutant HNF4α	Rat	Blunted insulin release induced by glucose	[93]
siRNA-mediated knockdown of HNF4α in isolated hepatocytes	Rat	Decreased glucose production	[94]
Hepatocyte-specific HNF4α deletion	Mouse	Disrupted lipid and carbohydrate homeostasis	[34]
Small hairpin RNA-mediated deletion of HNF4α	Mouse	Disrupted triglyceride and cholesterol homeostasis	[35]
Hepatocyte-specific HNF4α deletion	Mouse	Steatosis and depletion of glycogen	[33]
Liver-specific deletion	Mouse	Altered hepatic fatty acid metabolism	[95]
Antisense RNA or siRNA mediated knockdown of HNF4α in human hepatocytes	Human	Reduced expression of genes involved in drug metabolism	[28, 29]