TABLE 3.

Meta‐analytic estimates of adjusted dementia diagnosis–neuropathology associations moderated by personality traits and well‐being.

	Braak stage	CERAD	Lewy body disease	Gross cerebral infarcts	Gross cerebral microinfarcts	Cerebral athero‐sclerosis	Cerebral amyloid angiopathy	Arteriosclerosis	Hippocampal sclerosis	TDP‐43
Trait	b [CI]	b [CI]	OR [CI]	OR [CI]	OR [CI]	b [CI]	b [CI]	b [CI]	OR [CI]	OR [CI]
Extraversion		0.04 [−0.09, 0.18]	0.04 [−0.37, 0.61]	1.01 [0.84, 1.23]	1.07 [0.62, 2.65]	1.13 [0.90, 1.40]	0.03 [−0.07, 0.15]	0.04 [−0.06, 0.20]	0.02 [−0.07, 0.12]	1.02 [0.73, 1.41]
Agreeableness		0.05 [−0.15, 0.25]	−0.03 [−0.63, 0.56]	1.11 [0.75, 1.65]	1.08 [0.30, 4.40]	1.01 [0.43, 4.15]	0.05 [−0.37, 0.34]	−0.01 [−0.50, 0.36]	−0.02 [−0.49, 0.43]	0.99 [0.53, 2.01]
Conscientiousness		0.10 [−0.07, 0.26]	−0.05 [−0.29, 0.22]	1.06 [0.84, 1.32]	1.09 [0.65, 2.19]	1.15 [0.89, 1.49]	0.03 [−0.07, 0.15]	0.03 [−0.06, 0.14]	0.00 [−0.12, 0.12]	0.86 [0.57, 1.28]
Neuroticism		−0.07 [−0.21, 0.07]	0.07 [−0.16, 0.32]	1.10 [0.84, 1.40]	1.03 [0.57, 1.89]	0.92 [0.63, 1.45]	−0.03 [−0.14, 0.09]	−0.03 [−0.17, 0.12]	0.001 [−0.13, 0.12]	0.87 [0.62, 1.24]
Openness to experience		0.01 [−0.19, 0.25]	0.03 [−0.79, 0.74]	1.13 [0.85, 1.57]	1.01 [0.26, 3.79]	1.09 [0.58, 2.53]	−0.06 [−0.46, 0.29]	−0.00 [−0.41, 0.48]	0.03 [−0.42, 0.57]	1.24 [0.76, 2.26]
Positive affect		−0.02 [−0.88, 0.46]	−0.03 [−0.57, 0.48]	1.12 [0.67, 2.48]	0.93 [0.56, 1.73]	0.85 [0.44, 2.01]	−0.02 [−0.48, 0.39]	−0.05 [−0.34, 0.27]	0.02 [−0.48, 0.57]	1.12 [0.61, 2.85]
Negative affect		−0.12 [−2.01, 1.59]	−0.31 [−1.64, 1.31]	1.21 [0.22, 10.72]	1.05 [0.19, 6.33]	1.11 [0.14, 8.85]	−0.60 [−2.31, 1.44]	−0.02 [−1.64, 1.57]	−0.02 [−1.88, 1.47]	0.89 [0.15, 6.47]
Satisfaction with life		−0.12 [−1.39, 0.57]	−0.03 [−0.56, 0.39]	1.13 [0.58, 2.08]	0.83 [0.36, 1.73]	0.93 [0.44, 2.52]	−0.01 [−0.44, 0.41]	−0.05 [−0.54, 0.45]	−0.01 [−0.44, 0.39]	1.26 [0.25, 7.53]

Note: Adjusted models Include age, gender, education, smoking status, alcohol use, and prediction interval. Point estimates indicate the median of the posterior distribution, while interval estimates indicate the 95% credible interval (CI) of the posterior. For binary outcomes, these are exponentiated values to transform log odds to odds ratios. None of the 95% CIs overlapped with zero (before exponentiation for binary outcomes), indicating no significant meta‐analytic results.