Table 5.
Univariate and multivariate logistic regression analysis of clinical and genomic factors associated with HIV late presentation (LP).
Univariate and multivariate logistic regression analysis of clinical and genomic factors associated with HIV late presenter (LP) status | ||||
---|---|---|---|---|
Unadjusted | Adjusted (N = 325) | |||
OR (95% CI) | p-value | OR (95% CI) | p-value | |
Clinical | ||||
Age at diagnosis (groups) | ||||
18–24 | 1 | 1 | ||
25–34 | 1.18 (0.66–2.14) | 0.58 | 1.09 (0.54–2.23) | 0.8 |
35–44 | 2.69 (1.44–5.13) | 0.002 | 2.67 (1.28–5.7) | 0.01 |
45–54 | 4.91 (2.12–12) | < 0.001 | 4.11 (1.49–12.1) | 0.008 |
≥55 | 1.93 (0.57–6.42) | 0.28 | 4.18 (1–18.6) | 0.053 |
Viral load (copies/mL) | ||||
≤10,000 | 1 | 1 | ||
10,000–100,000 | 3.06 (1.41–7.39) | 0.007 | 12.9 (3.54–84.2) | < 0.001 |
≥100,000 | 9.62 (4.46–23.3) | < 0.001 | 33.6 (9.14–220) | < 0.001 |
HLA-B57 | ||||
Negative | 1 | |||
Positive | 0.36 (0.05–1.47) | 0.2 | ||
Genomic | ||||
Any SDRM | ||||
No | 1 | |||
Yes | 1.29 (0.58–2.85) | 0.53 | ||
Subtype | ||||
B | 1 | 1 | ||
A1 | 1.15 (0.57–2.27) | 0.69 | 1.57 (0.7–3.51) | 0.3 |
C | 2.20 (0.83–6.22) | 0.12 | 1.76 (0.54–6.05) | 0.4 |
Other | 0.84 (0.43–1.6) | 0.60 | 0.66 (0.31–1.37) | 0.3 |
Recombinant | 0.93 (0.39–2.16) | 0.88 | 0.95 (0.35–2.55) | >0.9 |
B vs. non-B | ||||
B | 1 | |||
Non-B | 1.08 (0.69–1.69) | 0.73 | ||
Ambiguity rate | 1.73 (1.25–2.5) | 0.002 | 1.52 (1.09–2.24) | 0.024 |
Recentness | ||||
Chronic | 1 | |||
Recent | 0.26 (0.17–0.42) | < 0.001 |
STI, Sexual transmitted infections.