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. Author manuscript; available in PMC: 2024 Mar 18.
Published in final edited form as: Magn Reson Chem. 2023 Apr 17;61(12):628–653. doi: 10.1002/mrc.5350

Table 1:

Summary of NIST and PTSD Metabolites Detected by Vendors[42]

Vendor NIST Metabolitesa Average Errorb Error Rangec PTSD Biomarkersd Coveragee Unique Metabolitesf Percent Changeg
Biocrates 24 −19.29% (−99.49% : 18.92%) 22 29% 0 −16%
HMT 13 −16.74% (−38.5% : 1.97%) 48 63% 3 11%
Lipotype 1 −40.33% N/A 24 32% 4 35%
Metabolon N/A N/A N/A 53 70% 4 61%
Nightingale 12 −1.03% (−19.63% : 15.25%) 12 16% 0 0%
Average 12.5 −19.35% (−49.49% : 12.05%) 31.8 42% - -
a

total number of metabolites detected by the vendor that matches known metabolites in the standard NIST plasma sample. The total number of known metabolites in the NIST plasma sample is 26.

b

average error in the quantification of the detected NIST metabolites.

c

error range in the quantification of the detected NIST metabolites.

N/A - not applicable; metabolon did not submit an analysis of the standard NIST plasma sample

d

total number of metabolites detected by the vendor that matches literature defined PTSD metabolite biomarkers. The total number of PTSD metabolite biomarkers identified from scientific literature is 76.

e

percentage of metabolites detected by the vendor that matches literature defined PTSD metabolite biomarkers.

f

the number of PTSD metabolite biomarkers detected by the vendor that was not detected by any other vendor.

g

percent change in the number of metabolites detected between two identical replicate sets of PTSD plasma samples.