Table 2.
Coagulation evaluation parameters.
| Parameters during episode | Results |
|---|---|
| Coagulation evaluations per episode, median (IQR) | 2 (1, 5; range 1–94)a |
| Timing of first coagulation evaluation relative to reference culture (h), median (IQR) | 14 (4, 45) |
| Age at first coagulation evaluation (days) | 14 (6, 40) |
| Frequency of any abnormal values on first testing (n = 96) | 78/96 (81%)b |
| Abnormal fibrinogen (n = 88 measures) | Low (7/88, 8%), elevated (23/88, 26%) |
| Abnormal PT (n = 94 measures) | All prolonged (60/94, 64%) |
| Abnormal PTT (n = 90 measures) | Prolonged (14/90, 16%), fast (6/90, 7%) |
| Frequency of any abnormal values on any testing | 271/339 (80%)c |
| Abnormal fibrinogen (n = 299 measures) | Low (14/299, 5%), elevated (58/299, 19%) |
| Abnormal PT (n = 336 measures) | All prolonged (230/336, 68%) |
| Abnormal PTT (n = 314 measures) | Prolonged (32/314, 10%), fast (21/314, 7%) |
| Timing of any abnormal result relative to reference culture (h), median (IQR) (n = 339) | 43 (17, 111)d |
| Timing of abnormal fibrinogen (h), median (IQR) | 43 (13, 118) |
| Timing of abnormal PT (h), median (IQR) | 45 (21, 151) |
| Timing of abnormal PTT (h), median (IQR) | 43 (13, 118) |
| Gestational age at birth among those with any abnormal value (weeks) | 32 (26, 38)e |
IQR, interquartile range; PT, prothrombin time; PTT, partial thromboplastin time.
a
Only first 10 coagulation evaluations of each episode were included in the analysis.
b
14/78 (18%) had either isolated hyperfibrinogenemia, a low PTT, or both.
c
239/339 (71%) had low fibrinogen, prolonged PT, or prolonged PTT.
d
Median timing of only abnormal (no high fib, low PTT, or combo included) 42 h (17, 103).
e
Median GA among only abnormal tests (no high fib, low PTT, or combo included) 32 weeks (27, 38).