Table 2.
Examples of fish β-parvalbumin peptide reactivities induced during the course of the study.
| Donor | Allergen | Isotype/subclass | Minimal epitope (colour in structure) | Epitope location | Illustration | |
|---|---|---|---|---|---|---|
| 7 | Gad c 1.0101 | IgG | FDEDGFYAK (blue) | B helix | Figure 8A |
|
| 4 | Gad m 1.0201 | IgG | LAAKSPADI (yellow) | BC loop and C helix N-terminus | Figure 9 | |
| 6 | Thu a 1.0101 | IgG | LAAKTPEDI | BC loop and C helix N-terminus | Supplementary Figure 5B | |
| 6 | Gad c 1.0101 | IgG | IADEDK | C helix C-terminus and CD loop | Supplementary Figure 5B | |
| 11 | Multiple allergens such as Clu h 1.0101 | IgG | KKAFEIIDQDK (magenta) | C helix C-terminus and CD loop | Supplementary Figure 5A | |
| 2 | Multiple allergens such as Thu a 1.0101 | IgG4 | FIEEDELKLFLQNFSA (orange) | D helix and flanks |
Figure 2
; Supplementary Figure 1 |
|
| 7 | Multiple allergens such as Gad m 1.0201 | IgG | ETKVFLKAGDSDGDGK (cyan) | E helix and EF loop | Figures 8B-D |
Epitopes are modeled onto the structure of Gad m 1 (PDB: 2MBX) and shown in two orientations with loops holding calcium ions (spheres) positioned on top.