Table 1.
Baseline characteristics of participants with or without IMDs in UKB.
| Without IMDs | With IMDs | P-value | |
|---|---|---|---|
| (N=404631) | (N=29813) | ||
| Sex | |||
| Male | 186959 (46.2%) | 12059 (40.4%) | <0.001 |
| Female | 217672 (53.8%) | 17754 (59.6%) | |
| Age (years) | |||
| Median [Q3-Q1] | 57.0 [63.0-50.0] | 59.0 [64.0-52.0] | <0.001 |
| BMI (kg/m2) | |||
| Median [Q3-Q1] | 26.6 [29.6-24.0] | 27.7 [31.6-24.7] | <0.001 |
| Smoking | |||
| Never | 224522 (55.5%) | 14688 (49.3%) | <0.001 |
| Previous | 135799 (33.6%) | 11466 (38.5%) | |
| Current | 42090 (10.4%) | 3406 (11.4%) | |
| TDI | |||
| Median [Q3-Q1] | -2.19 [0.419–3.67] | -1.57 [1.56–3.37] | <0.001 |
| Alcohol | |||
| Never | 16926 (4.2%) | 2010 (6.7%) | <0.001 |
| Previous | 12884 (3.2%) | 2097 (7.0%) | |
| Current | 373569 (92.3%) | 25560 (85.7%) | |
| Education | |||
| College or University degree | 134781 (33.3%) | 7362 (24.7%) | <0.001 |
| A levels/AS levels or equivalent | 45535 (11.3%) | 2856 (9.6%) | |
| O levels/GCSEs or equivalent | 84960 (21.0%) | 6208 (20.8%) | |
| CSEs or equivalent | 21770 (5.4%) | 1715 (5.8%) | |
| NVQ or HND or HNC or equivalent | 25931 (6.4%) | 2080 (7.0%) | |
| Other professional qualifications | 20280 (5.0%) | 1689 (5.7%) | |
| None of the above | 63677 (15.7%) | 7217 (24.2%) | |
| ALS | |||
| No | 404216 (99.9%) | 29767 (99.8%) | 0.0106 |
| Yes | 415 (0.1%) | 46 (0.2%) | |
ALS, amyotrophic lateral sclerosis; BMI, body mass index; IMD, immune-mediated diseases.
*P<0.05, **P<0.01, ***P<0.001.