Table 3.
Sensitive analysis of the peripheral immune markers on ALS incidence.
| Organ_specific_IMD | Sensitivity 1 | Sensitivity 2 | |||
|---|---|---|---|---|---|
| HR (95% CI) | P-value | HR (95% CI) | P-value | ||
| All_IMD | 1.24(1.02-1.52) | 0.034* | 1.25(1.01-1.55) | 0.040* | |
| D_IMD | Diseases of the blood and blood-forming organs | 1.75(0.25-12.49) | 0.574 | 2.01 (0.28-14.29) | 0.486 |
| E_IMD | Endocrine, nutritional and metabolic diseases | 3.11(1.54-6.27) | 0.002** | 2.70 (1.20-6.06) | 0.016* |
| G_IMD | Diseases of the nervous system | 1.01 (0.14-7.19) | 0.992 | 0 (0.00-Inf) | 0.985 |
| I_IMD | Diseases of the circulatory system | 1.07 (0.15-7.62) | 0.946 | 1.24 (0.17-8.81) | 0.831 |
| J_IMD | Diseases of the respiratory system | 1.02 (0.63-1.67) | 0.923 | 0.96 (0.56-1.64) | 0.887 |
| K_IMD | Diseases of the digestive system | 2.15 (1.18-3.90) | 0.012* | 2.01 (1.04-3.88) | 0.039* |
| L_IMD | Diseases of the skin and subcutaneous tissue | 1.62 (0.52-5.03) | 0.407 | 0.62 (0.09-4.39) | 0.629 |
| M_IMD | Diseases of the musculoskeletal system and connective tissue | 1.34 (0.60-3.01) | 0.472 | 1.03 (0.38-2.76) | 0.952 |
Sensitive analysis 1 was sensitive analysis of IMDs on ALS incidence with excluding ALS patients with a latency shorter than 1 year from initial sampling to diagnosis (1 year).
Sensitive analysis 2 was sensitive analysis of IMDs on ALS incidence with excluding ALS patients with a latency shorter than 3 years from initial sampling to diagnosis (3 years).
ALS, amyotrophic lateral sclerosis; BMI, body mass index; IMD, immune-mediated diseases; HR, hazard ratio; CI, confidence interval.
*P<0.05, **P<0.01, ***P<0.001.