Table 4.

Peripheral immunity and ALS risk across different IMD duration, CRP, and Sex subgroups.

		Any_IMD
		HR (95% CI)	P-value
IMD Duration	<5y	1.50(0.99-2.26)	0.055
	>=5y, <10y	1.12(0.64-1.94)	0.699
	>=10y	2.17(1.12-4.21)	0.022 *
CRP	<1.3mmol/L	1.07 (0.56-2.02)	0.841
	>=1.3mmol/L	1.57(1.09-2.28)	0.016 *
Sex	female	1.62(1.06-2.48)	0.025 *
	male	1.24(0.79-1.95)	0.341

Model 1 adjusted for age, sex. Model 2 adjusted for age, sex, education, Townsend deprivation index. Model 3 adjusted for age, sex, education, Townsend deprivation index, BMI, smoking, alcohol consumption.

IMD, immune-mediated diseases; CRP, C-reactive protein; HR, hazard ratio; CI, confidence interval.

*P<0.05, **P<0.01, ***P<0.001.