Table 2.

Risk of anastomotic leak controlling for the competing risk of death, clustered at the institutional level

	Multivariate analysis A			Multivariate analysis Ba
	SHR	95% CI	p-value	SHR	95% CI	p-value
DLI (ref = no DLI)	0.42	0.27–0.65	< 0.001	0.36	0.23–0.57	< 0.001
Age	1.0–0	0.98–1.02	0.73	0.98	0.98–1.02	0.85
Male sex (ref = female sex)	2.59	1.70–3.95	< 0.001	1.43	1.43–3.81	0.001
Weight loss (ref = no preoperative weight loss)				0.88	0.88–2.95	0.12
Neoadjuvant CRT (ref = no neoadjuvant CRT)				0.67	0.67–2.44	0.45
Active smoking (ref = non-smokers)				0.46	0.46–2.78	0.80

Bolded values indicate statistical significance

DLI diverting loop ileostomy, SHR subhazard ratio, CI confidence interval, CRT chemoradiation, ref reference

^aGiven the limited number of AL events, Fine-Gray models were created with a limited number of variables that were significant on univariate analysis to avoid overfitting (analysis A). A second analysis (analysis B) included a greater number of clinically relevant variables