Table 4.
Incidence rates (IRs) and hazard ratios (HRs) of malignant neoplasms in patients compared to matched controls.
| events | pyrs | IR [95% CI] a | Crude HR [95% CI] | Adjusted HR [95% CI], restricted model b | Adjusted HR [95% CI], full model c | |
|---|---|---|---|---|---|---|
| Controls (n=50 036) | 1 310 | 1 038 390 | 12.6 [11.9-13.3] | 1.00 (Ref) | 1.00 (Ref) | 1.00 (Ref) |
| Patients (n=3 408) | 71 | 71 662 | 9.9 [7. 9-12.5] | 0.78 [0.62-0.99] | 0.93 [0.69-1.25] | 0.91 [0.66-1.26] |
| Male controls (n=33 861) | 425 | 726 023 | 5.9 [5.3-6.4] | 1.00 (Ref) | 1.00 (Ref) | 1.00 (Ref) |
| Male patients (n=2 305) | 18 | 50 076 | 3.6 [2.3-5.7] | 0.61 [0.38-0.98] | 0.73 [0.42-1.27] | 0.73 [0.41-1.32] |
| Female controls (n=16 175) | 885 | 312 367 | 28.3 [26.5-30.3] | 1.00 (Ref) | 1.00 (Ref) | 1.00 (Ref) |
| Female patients (n=1 103) | 53 | 21 586 | 24.6 [18.8-32.1] | 0.86 [0.65-1.14] | 1.02 [0.71-1.47] | 1.01 [0.68-1.49] |
a
Events/10 000 pyrs.
b
Restricted model adjusted only for age at start, height at start and sex.
c
Full model adjusted for gestational age, birth length, birth weight, age at start, height at start, parental educational level, family income and sex.