Table 2.
Factors affecting OS and DFS as per Cox regression
| Characteristic | Variable | HR (OS) | 95% CI (OS) | p Value (OS) | HR (RFS) | 95% CI (RFS) | p value |
|---|---|---|---|---|---|---|---|
| Age | < 50 | ||||||
| > 50 | 0.6 | 0.7 to 1.4 | 0.32 | 0.46 | 0.72 to 1.6 | 0.48 | |
| Sex | Male | ||||||
| Female | 0.55 | 0.27 to 1.1 | 0.09 | 0.81 | 0.32 to 2.0 | 0.66 | |
| Location | Middle | ||||||
| Lower | 1.0 | 0.79 to 1.5 | 0.57 | 1.3 | 0.81 to 2.1 | 0.26 | |
| Neoadjuvant chemotherapy | Single | ||||||
| Dual | 1.1 | 0.58 to 2.2 | 0.70 | 0.52 | 0.21 to 1.3 | 0.17 | |
| Histological differentiation | WD | ||||||
| MD | 1 | 0.52 to 1.9 | 1 | 0.8 | 0.8 to 1.4 | 0.43 | |
| PD | 0.98 | 0.43 to 2.2 | 0.96 | 0.59 | 0.43 to 1.59 | 0.51 | |
| NOS | 2.4 | 0.90 to 3.1 | 0.06 | 0 | 0 to infinity | 0.97 | |
| Type of surgery | VATS | ||||||
| Open | 1.01 | 0.64 to 2.0 | 0.64 | 22.4 | 0 to infinity | 0.95 | |
| THE | 1.11 | 0.39 to 2.6 | 0.95 | 0 | 0 to infinity | 0.94 | |
| Pathological complete response | Yes | ||||||
| No | 1.45 | 0.99 to 2.14 | 0.057 | 1.5 | 0.87 to 2.6 | 0.13 | |
| Lymph node positivity | Yes | ||||||
| No | 1.1 | 0.79 to 1.5 | 0.50 | 0.94 | 0.59 to 1.5 | 0.80 | |
| Type of lymphadenectomy | E2F | ||||||
| 2F | 0.7 | 0.36 to 1.5 | 0.42 | 16 | 0 to Infinity | 0.98 | |
| 1F | 1.6 | 0.61 to 4.2 | 0.32 | 0 | 0 to infinity | 0 | |
RFS recurrence-free survival, OS overall survival, HR hazard ratio, CI confidence intervalm, WD well differentiated, MD moderately differentiated, PD poorly differentiated, NOS not otherwise specified, VATS video-assisted thoracoscopic surgery, THE transhiatal esophagectomy, E2F extended two field, 2F two field, 1F single field