Fig. 2. Substrate scope for synthesis of meta-carbonyl phenols.

a Substrate scope of aryl ketones. b Substrate scope of conjugated enones. c Substrate scope of aliphatic ketones and aldehydes. Reaction conditions: substrate (0.25 mmol), CuI (10 mol%), AgOAc (9 mol%), and TFA (10.0 equiv) in DMSO (1 mL), H₂O (50 μL) under O₂ at 90 ^oC for 60 h. Isolated yields are reported. ^aReaction conducted with 1a (5.5 mmol). ^bAgOAc (9.5 mol%) was used. ^c48 h. ^d100 ^oC. ^eNo addition of H₂O. ^fPd(OAc)₂ (15 mol%) was used instead of AgOAc.