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. 2024 Mar 18;15:2415. doi: 10.1038/s41467-024-46576-2

Fig. 3. Substrate scope for synthesis of meta-carbonyl anilines.

Fig. 3

a Substrate scope of anilines. b Substrate scope of aromatic ketones. c Substrate scope of N-acetyl anilines. d Substrate of N-propionyl aniline. e Substrate of N-tert-butoxycarbonyl aniline. Reaction conditions: 1 (0.25 mmol), 11 (0.5 mmol) or 14 (0.5 mmol) or 15 (0.5 mmol), CuI (10 mol%), TBHP (2.2 equiv), and TFA (10.0 equiv) in DMSO (1 mL) at 90 oC for 60 h. Isolated yields are reported. aTBHP (1.1 equiv). bTBHP (2.0 equiv). c36 h. dAgOAc (9 mol%) instead of TBHP. Boc, tert-butoxycarbonyl.