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. 2024 Mar 18;15:2328. doi: 10.1038/s41467-024-46373-x

Fig. 2. Expression of hair keratin homologs of Xenopus tropicalis is associated with cornified claws.

Fig. 2

a Schematic depiction of a clawed frog (X. tropicalis) bearing cornified claws on the hindlimb inner (HI) toes (toes I, II, III) and no claws on the hindlimb outer (HO) toes (toes IV, V) and on toes of the forelimbs. b Schematic of a frog clawed toe tip. The term “claw” refers to the cornified claw that is formed by the differentiation of the epithelium on the tip of the toe. c–e Quantitative RT-PCR analysis of mRNA expression of krt34 (c), krt59 (d), krt53 (e) relative to the housekeeping gene, eef1a1. Mass-spectrometric quantification of Krt34 (f), Krt59 (g) and Krt53 (h). a.u., arbitrary units. RNA and protein were sampled at an age of 7 months. Statistics was calculated by one-way ANOVA for n = 4 (c–e) and three (f–h) biological replicates, respectively, in each of 3 groups. Bars and error bars indicate means and standard deviations, respectively.