Table 2.
Associations between clinical variables and FA within all BD patients.
| Variable | Negative | Positive |
|---|---|---|
| Number of depressive episodes | ptfce-FWE = 0.057 | ptfce-FWE = 0.737 |
| Number of (hypo-) manic episodes | ptfce-FWE = 0.05 | ptfce-FWE = 0.93 |
| Number of psychiatric hospitalizations | ptfce-FWE = 0.938 | ptfce-FWE = 0.108 |
| Time since first psychiatric hospitalization | ptfce-FWE = 0.989 | ptfce-FWE = 0.021 |
| Time since first symptoms | ptfce-FWE = 0.532 | ptfce-FWE = 0.505 |
| Psychotic symptoms (yes vs. no)a | ptfce-FWE = 0.472 | |
| Medication load | ptfce-FWE = 0.616 | ptfce-FWE = 0.318 |
| PRS-CS-auto (mean φ = 1.29 × 10−4) for BD | ptfce-FWE = 0.971 | ptfce-FWE = 0.278 |
| Childhood adversityb | ptfce-FWE = 0.081 | ptfce-FWE = 0.889 |
| Body Mass Index | ptfce-FWE = 0.056 | ptfce-FWE = 0.718 |
p values are considered significant at p < 0.005, correcting for multiple testing by the Bonferroni procedure, aaccording to pairwise comparison (t-test) comparing patients with and without lifetime psychotic symptoms across both BD subtype groups, bmeasured by the Childhood Trauma Questionnaire (CTQ).
BD bipolar disorder, BD-I bipolar disorder subtype I, BD-II bipolar disorder subtype 2, FA fractional anisotropy, PRS polygenic risk score.