Table 3.

Associations between clinical variables and GMV within all BD patients.

Variable	Negative	Positive
Number of depressive episodes	ptfce-FWE = 0.162	ptfce-FWE = 0.589
Number of (hypo-) manic episodes	ptfce-FWE = 0.427	ptfce-FWE = 0.831
Number of psychiatric hospitalizations	ptfce-FWE = 0.132	ptfce-FWE = 0.999
Time since first psychiatric hospitalization	ptfce-FWE = 0.416	ptfce-FWE = 0.785
Time since first symptoms	ptfce-FWE = 0.329	ptfce-FWE = 0.646
Age of Onset	ptfce-FWE = 0.646	ptfce-FWE = 0.329
Psychotic symptoms (yes vs. no)a	ptfce-FWE = 0.356
Medication Load	ptfce-FWE = 0.072	ptfce-FWE = 0.999
PRS-CS-auto (mean φ = 1.29×10-4) for BD	ptfce-FWE = 0.571	ptfce-FWE = 0.314
Childhood Adversityb	ptfce-FWE = 0.098	ptfce-FWE = 0.988
Body Mass Index	ptfce-FWE = 0.546	ptfce-FWE = 0.621

p-values are considered significant at p < 0.005, correcting for multiple testing by the Bonferroni procedure, ^aaccording to pairwise comparison (t-test) comparing patients with and without lifetime psychotic symptoms across both BD subtype groups, ^bmeasured by the Childhood Trauma Questionnaire (CTQ).

BD bipolar disorder, BD-I bipolar disorder subtype I, BD-II bipolar disorder subtype 2, GMV gray matter volumes, PRS polygenic risk score.