Table 2.
Summary of nicotine vapour effects on behaviour, pharmacokinetics, and network connectivity. Data expressed as mean ± SEM.
| Measure | Age | Sex | Finding | ||
|---|---|---|---|---|---|
| Place Conditioning | Adult | Male | No CPP at 600 s exposure | ||
| Female | CPP at 480 and 600 s exposures | ||||
| Adolescent | Male | No CPP at 600 s exposure | |||
| Female | No CPP | ||||
| Withdrawal symptoms | Adult | Male | Withdrawal | ||
| Female | No withdrawal | ||||
| Adolescent | Male | Withdrawal | |||
| Female | No withdrawal | ||||
| Locomotion | Adult | Male | Increased locomotion | ||
| Female | No effect on locomotion | ||||
| Adolescent | Male | Increased locomotion | |||
| Female | No effect on locomotion | ||||
| Weight | Adult | Male | No effect on weight gain | ||
| Female | Decreased weight gain | ||||
| Adolescent | Male | Decreased weight gain | |||
| Female | No effect on weight gain | ||||
| Nicotine Pharmaco-kinetics (Plasma; ng/mL) | Time point | 10 min (venous) | 30 min (arterial) | 60 min (arterial) | |
| Adult | Male | 152.0 ± 30.1 | 106.0 ± 18.2 | 96.5 ± 11.1 | |
| Female | 287.7 ± 29.5 | 195.7 ± 26.1 | 178.5 ± 16.7 | ||
| Adolescent | Male | 175 ± 38.1 | 126.9 ± 16.9 | 82.2 ± 15.5 | |
| Female | 145 ± 36.8 | 177.8 ± 26.1 | 127.0 ± 30.1 | ||
| Nicotine Pharmaco-kinetics (Brain; ng/g) | Time point | 10 min | 30 min | 60 min | |
| Adult | Male | - | 193.6 ± 30.6 | 93.6 ± 12.5 | |
| Female | - | 514.0 ± 77.5 | 333.5 ± 26.5 | ||
| Adolescent | Male | - | 259.3 ± 31.2 | 192.0 ± 33.5 | |
| Female | - | 561.1 ± 62.6 | 397.7 ± 75.0 | ||
| Functional Connectivity | Decreased NBS and between component group connectivity in nicotine vapour exposed animals; significant interaction with sex, with females showing further reductions in connectivity (NBS) | ||||
| Structural Connectivity | No effect on diffusion (NBS) | ||||