Table 2.

1H-MRS metabolite estimates at baseline and 12 weeks for the three groups.

	Responders	Nonresponders	HC
pACC
Baseline
Sample size	27	14	41
Glutamate	15.54 ± 3.71	19.15 ± 5.80	16.56 ± 4.15
Glx	19.84 ± 4.35	23.73 ± 8.43	21.40 ± 6.13
12 weeks
Sample size	23	10	___
Glutamate	15.54 ± 2.53	16.25 ± 3.59	___
Glx	18.81 ± 3.23	21.64 ± 3.58	___
dACC
Baseline
Sample size	27	15	41
Glutamate	12.82 ± 2.81	14.45 ± 2.42	13.53 ± 1.85
Glx	15.61 ± 3.27	17.88 ± 2.96	16.54 ± 2.36
12 weeks
Sample size	23	11	___
Glutamate	12.31 ± 1.33	12.81 ± 1.91	___
Glx	15.03 ± 1.87	15.39 ± 2.68	___

Data are presented as mean ± standard deviation. pACC: anterior cingulate cortex at ventral and perigenual voxel; dACC: dorsal anterior cingulate cortex; Glx: glutamate + glutamine. The unit of neurometabolite measurements is mM.