Table 2.

Association of allergic diseases with ASQ-3 developmental milestones.

Allergic diseases	Child, No. (%)a	ASQ-3 domains OR (95% CI)
		Communication skills		Gross motor skills		Fine motor skills		Problem-solving skills		Personal-social skills
Atopic dermatitis		Model 1b	Model 2c	Model 1b	Model 2c	Model 1b	Model 2c	Model 1b	Model 2c	Model 1b	Model 2c
No	47,438 (90.0)	1 [Reference]	1 [Reference]	1 [Reference]	1 [Reference]	1 [Reference]	1 [Reference]	1 [Reference]	1 [Reference]	1 [Reference]	1 [Reference]
Yes	5259 (10.0)	1.01 (0.90–1.15)	1.03 (0.90–1.19)	1.00 (0.92–1.09)	0.94 (0.84–1.04)	1.04 (0.96–1.13)	1.04 (0.95–1.14)	1.04 (0.96–1.12)	1.03 (0.94–1.13)	0.97 (0.85–1.10)	0.93 (0.90–1.08)
Asthma
No	47,436 (90.0)	1 [Reference]	1 [Reference]	1 [Reference]	1 [Reference]	1 [Reference]	1 [Reference]	1 [Reference]	1 [Reference]	1 [Reference]	1 [Reference]
Yes	5255 (10.0)	0.78 (0.68–0.89)d	0.77 (0.68–0.88)d	0.99 (0.91–1.08)	0.98 (0.90–1.07)	0.98 (0.90–1.08)	0.97 (0.89–1.05)	0.95 (0.83–1.02)	0.93 (0.81–1.04)	0.88 (0.77–1.03)	0.86 (0.73–1.02)
Food allergy
No	45,859 (87.0)	1 [Reference]	1 [Reference]	1 [Reference]	1 [Reference]	1 [Reference]	1 [Reference]	1 [Reference]	1 [Reference]	1 [Reference]	1 [Reference]
Yes	6238 (13.0)	0.96 (0.87–1.07)	0.95 (0.84–1.08)	1.12 (1.04–1.21)d	1.14 (1.04–1.24)d	1.05 (0.98–1.12)	1.02 (0.93–1.11)	1.02 (0.96–1.10)	1.01 (0.93–1.09)	1.04 (0.93–1.15)	1.07 (0.94–1.02)

OR, Odds ratio; CI, confidence interval; ASQ-3, Ages and Stages Questionnaires, third edition.

^aData are expressed as weighted No. (%).

^bWeighted OR. Weighted OR were derived via propensity score-based, stabilized inverse probability-weighted generalized estimating equations models.

^cWeighted adjusted OR; adjusted for other allergic diseases.

^dp < 0.01.