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. 2024 Mar 13;19:2553–2571. doi: 10.2147/IJN.S452824

Figure 4.

Figure 4

In vitro anti-atherosclerotic efficacy of P-ENVs. (A) Representative ORO images of ox-LDL-loaded VSMCs and (B) quantitative analysis of ORO area after treatment with PBS, ENVs, or P-ENVs in vitro. Scale bar = 50 um. n = 6. (C) Total cholesterol levels in foam cells after treatment with PBS, ENVs, or P-ENVs in vitro. n = 3. (D) Quantitative analysis of APOA-I mediated cholesterol efflux (%) in control, ENV, or P-ENV group and (E) representative fluorescent images of the NBD-cholesterol accumulation in foam cells obtained from these groups after incubation with APOA-I for 4 h. (green: NBD-cholesterol, blue: nuclei). Scale bar = 20 um. n = 3. (F) Western blot analysis and (G) quantification of ABCA1 and ABCG1 after various treatments in vitro. n = 3. All data are presented as mean ± SD (*P < 0.05, **P < 0.01, ***P < 0.001).