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. 2024 Mar 13;19:2553–2571. doi: 10.2147/IJN.S452824

Figure 5.

Figure 5

In vivo anti-atherosclerotic efficacy of P-ENVs. (A) Schematic diagram of the 4-week treatment of P-ENVs in ApoE−/− mice. (B) Representative images of en face ORO-stained aortas after treatment with PBS, ENVs, or P-ENVs in vivo. Scale bar = 10 mm. n = 6. (C) Quantification of plaque area in aortas. (D) Representative ORO and H&E images of aortic roots and quantitative analysis on (E) plaque area and (F) necrotic core after treatment with PBS, ENVs, or P-ENVs. Scale bar = 200 um. n = 5 or 6. (G) Western blot analysis and (H) quantification of ABCA1 and ABCG1 after 4-week treatment with PBS, ENVs, or P-ENVs in vivo. n = 3. All data are presented as mean ± SD (*P < 0.05, **P < 0.01, ***P < 0.001).