FIG. 6.
Long-term persistence of vector DNA in the livers and lungs of CBA/J and SCID mice. Totals of 2 × 109 IU of AdE1° (A and B) and AdE1°E4 (C and D) and 109 PFU of AdE1°E2A° (E and F) were injected intravenously into SCID (•) and CBA/J (○) mice. DNA from livers (A, C, and E) and lungs (B, D, and F) was prepared at the indicated times and analyzed by Southern blotting and densitometry scanning. Symbols represent the means ± SE for 8 (A to D) and 10 (E and F) CBA/J animals and for 6 (A and B), 5 (C and D), and 10 (E and F) SCID mice.