FIG. 8.
Anti-Ad antibodies in CBA/J mice. Mice were injected intravenously with 109 IU of AdE1° (A) and AdE1°E4° (C) and 109 PFU of AdE1°E2A° (B) vectors. Sera were collected at days 4 (▪), 35 (▴), and 90 (•) postinjection and analyzed by ELISA as previously described (37). Data are expressed as the means of the optical density at 450 nm (O.D. 450) ± SE determined for successive serial dilutions of the sera recovered from 5 to 10 mice per experimental group. Each plate contained the same positive control serum (▾).