TABLE 1.
Genomic organization of the recombinant Ad vectorsa
| Vector | Virus | Expression cassette | E1 | E2A | E4 |
|---|---|---|---|---|---|
| AdE1° | AdRSVβgal | RSV-lacZ | Deleted | wtb | wt |
| AdE1° | AdTG4656 | MLP-lacZ | Deleted | wt | wt |
| AdE1°E2A° | AdTG9542 | MLP-lacZ | Deleted | Deleted | wt |
| AdE1°E4° | AdTG8595 | MLP-lacZ | Deleted | wt | Deleted |
| AdE1°E4° | AdTG5643 | CMV-CFTRc | Deleted | wt | Deleted |
| AdE1° | AdTG6401 | Deleted | wt | wt | |
| AdE1°E2A° | AdTG9592 | Deleted | Deleted | wt | |
| AdE1°E4° | AdTG9546 | Deleted | wt | Deleted | |
| AdE1+E4° | AdTG9572 | wt | wt | Deleted |
a
All vectors contain a deletion (nt 28592 to 30480) in the viral E3 region.
b
wt, wild type.
c
CFTR, cystic fibrosis transmembrane conductance regulator.