Table 2.
Immunological profile and histopathological characteristics of the studied RPGN patients
| Variables | Type I RPGN n = 20 |
Type II RPGN n = 48 |
Type III RPGN n = 33 |
|---|---|---|---|
| Low C3 (%) | 2 (10%) | 42 (87.5%) | 0 (0%) |
| Low C4 (%) | 0 (0%) | 34 (70.8%) | 0 (0%) |
| +ve ANA (%) | 0 (0%) | 34 (70.8%) | 0 (0%) |
| +ve AntidsDNA (%) | 0 (0%) | 34 (70.8%) | 0 (0%) |
| +ve AntiGBM Ab (%) | 16 (80%) | 0 (0%) | 0 (0%) |
| +ve P-ANCA (%) | 0 (0%) | 0 (0%) | 13 (39.4%) |
| +ve C-ANCA (%) | 0 (0%) | 0 (0%) | 8 (24.2%) |
| Total number of glomeruli |
20 (4) 15–26 |
20 (6.75) 12–30 |
17 (8) 12–24 |
| Number of normal glomeruli |
3.0 (1) 1–6 |
4 (3) 1–14 |
4 (2) 0–10 |
| Number of sclerotic glomeruli |
7 (6) 0–9 |
4 (4) 0–8 |
3 (6) 0–7 |
| Number of crescentic glomeruli |
11.5 (4) 9–15 |
11 (3) 7–19 |
12 (5.5) 5–15 |
| Number of fibrous crescents |
3 (2) 1–7 |
2.5 (1.75) 0–5 |
2 (3) 0–6 |
| Number of cellular crescents |
8.5 (3) 5–12 |
9 (4.75) 5–16 |
8 (6) 4–14 |
| Glomerular lesions (%) | |||
|
• Endocapillary proliferation (%) • Mesangial proliferation (%) • Neutrophilic infiltration (%) • Glomerular thrombosis (%) |
0 (0%) 10 (50%) 12 (60%) 2 (10%) |
48 (100%) 26 (54.2%) 32 (66.7%) 0 (0%) |
2 (6.1%) 15 (45.5%) 23 (69.7%) 7 (21.2%) |
| Moderate to severe IFTA (%) | 14 (70%) | 24 (50%) | 16 (48.5%) |
| TLO formation (%) | 10 (50%) | 22 (45.8%) | 16 (48.5%) |
| Vascular lesions | |||
|
• Fibrinoid necrosis (%) • Degree of severe arteriosclerosis (%) |
3 (15%) 8 (40%) |
15 (31.3%) 26 (54.2%) |
13 (39.4%) 14 (42.4%) |
| Treatment | |||
| Steroid, CYC as induction then steroid, AZA as maintenance | 0 (0%) | 30 (62.5%) | 29 (87.9%) |
| Steroid, rituximab | 0 (0%) | 6 (12.5%) | 4 (12.1%) |
| Steroid, CYC, plasmapheresis as induction then steroid, AZA as maintenance | 20 (100%) | 12 (25%) | 0 (0%) |
ANA: antinuclear antibody, ANCA: anti-neutrophil cytoplasmic antibody, Anti-GBM: anti-glomerular basement membrane antibody, IFTA: interstitial fibrosis and tubular atrophy, TLO: tertiary lymphoid organ, RPGN: rapidly progressive glomerulonephritis
Data were expressed as number (%), or median (Interquartile range) and minimum-maximum