Table 4.
Most parsimonious Cox models of independent predictors of IHD, HF and all-cause death in the FDS2 cohort with CAN category defined (n = 830) and added
| HR (95% CI) | P-value | |
|---|---|---|
| IHD (n = 651) | ||
| Diabetes duration (increase of 1 year) | 1.02 (1.004, 1.04) | 0.021 |
| Heart rate (increase of 1 beat/min) | 1.02 (1.005, 1.03) | 0.009 |
| Ln(uACR)a | 1.21 (1.08, 1.35) | 0.001 |
| Distal symmetrical polyneuropathy | 1.29 (1.05, 1.57) | 0.014 |
| CAN category: none | 1.00 | |
| Possible | 0.96 (0.66, 1.41) | 0.851 |
| Definite | 1.00 (0.60, 1.68) | 0.993 |
| HF (n = 788) | ||
| Age (increase of 1 year) | 1.05 (1.02, 1.07) | < 0.001 |
| Aboriginal descent | 2.79 (1.51, 5.18) | 0.001 |
| Diabetes duration (increase of 1 year) | 1.03 (1.01, 1.05) | 0.011 |
| Ln(uACR)a | 1.33 (1.18, 1.49) | < 0.001 |
| Distal symmetrical polyneuropathy | 1.49 (1.19, 1.85) | < 0.001 |
| Peripheral arterial disease | 1.66 (1.11, 2.48) | 0.013 |
| Ischaemic heart disease | 1.95 (1.32, 2.88) | 0.001 |
| CAN category: None | 1.00 | |
| Possible | 0.94 (0.61, 1.46) | 0.789 |
| Definite | 1.27 (0.78, 2.06) | 0.342 |
| All-cause mortality (n = 827) | ||
| Age (increase of 1 year) | 1.07 (1.05, 1.09) | < 0.001 |
| Male sex | 1.55 (1.12, 2.15) | 0.008 |
| Aboriginal descent | 8.82 (3.20, 24.3) | < 0.001 |
| Other European ethnic background | 0.36 (0.16, 0.79) | 0.011 |
| Antidepressant therapy | 3.06 (1.29, 7.26) | 0.011 |
| Angiotensin receptor blocker use | 1.42 (1.03, 1.95) | 0.031 |
| eGFR < 30 mL/min/1.73m2 | 2.82 (1.40, 5.69) | 0.004 |
| Distal symmetrical polyneuropathy | 1.14 (0.94, 1.38) | 0.174 |
| Cerebrovascular disease | 1.67 (1.03, 2.73) | 0.039 |
| HF | 2.42 (1.42, 4.13) | 0.001 |
| CAN category: None | 1.00 | |
| Possible | 1.47 (1.01, 2.14) | 0.046 |
| Definite | 2.42 (1.60, 3.67) | < 0.001 |
| Time-varying covariates | ||
| Aboriginal descent | 0.42 (0.24, 0.75) | 0.003 |
| Antidepressant therapy | 0.62 (0.39, 0.99) | 0.047 |
Hazard ratios (HR) and 95% confidence intervals (95% CI) are shown. The proportional hazards assumption was violated in the model for all-cause mortality but not for IHD or HF
aA 2.72-fold increase in urinary albumin:creatinine ratio corresponds to an increased risk of 1 in ln(urinary albumin:creatinine)