Skip to main content
. 2024 Mar 19;24:196. doi: 10.1186/s12887-024-04633-1

Table 2.

Renal function parameters before and after administration of ifosfamide and acute changes during chemotherapy cycles

Pre-chemotherapy 24 h-post-chemotherapy Acute change* (%)
n Median (min-max) n Median (min-max) Median (min-max)
Glomerular parameters
eGFR (ml/min/1.73m2) 89 126 (54–171) 81 136 (81–206) 8 (-25-66)
Plasma creatinine (µmol/L) 89 45 (29–113) 81 42 (28–75) -7.3 (-39.7-33.3)
Plasma cystatin C (mg/L) 68 0.7 (0.5–1.1) 61 0.8 (0.3–1.1) 5.5 (-23.0-34.8)
Urine albumin/creatinine (mg/mmol) 90 1.2 (0.1–8.4) 89 0.1 (0.1–18.3) 0.0 (-99.4-15008.7)
Tubular parameters
Plasma sodium (mmol/l) 89 139 (134–145) 81 137 (132–143) -1.4 (-6.3-1.5)
Plasma potassium (mmol/l) 89 3.8 (3.1–4.7) 81 3.7 (2.9–6.9) -2.4 (-38.3-76.9)
Plasma bicarbonate (mmol/l) 89 25.5 (18.1–30.3) 81 24.5 (19.4–30.3) -2.7 (-27.7-28.2)
Plasma protein (mg/l) 89 70 (60–83) 81 69 (60–82) 0.0 (-13.3-13.0)
Plasma calcium (mmol/l) 89 2.3 (2.1–2.6) 81 2.3 (2.0-2.6) 0.4 (-9.2-12.6)
Plasma magnesium (mmol/l) 89 0.8 (0.6-1.0) 81 0.8 (0.6–1.1) 1.3 (-19.2-21.3)
Plasma phosphate (mmol/l) 89 1.4 (0.8–1.7) 81 1.1 (0.7–1.5) -13.7 (-48.3-32.3)
Fractional excretion of phosphate (%) 89 9.5 (3.6–19.1) 81 18.8 (8.3–37.0) 120.9 (-20.7-351.3)
Tmp/GFR (mmol/l) 89 1.2 (0.6–1.6) 81 0.9 (0.4–1.3) -22.5 (-62.7-18.1)
Plasma uric acid (µmol/L) 89 184 (105–410) 81 136 (72–287) -27.7 (-56.1-4.5)
Fractional excretion of uric acid (%) 89 8.6 (2.7–19.0) 81 24.8 (9.3–41.7) 193.0 (12.7-513.8)
Fractional excretion of glucose (%) 89 0.1 (0.0-0.4) 86 0.1 (0.0–23.0) 75.4 (-87.1-229843.1)
Urine calcium/creatinine (mmol/mmol) 90 0.5 (0.1–1.9) 88 0.9 (0.1–2.1) 70.3 (-56.4-858.2)
Urine β2-microglobulin/creatinine (mg/mol) 90 6.0 (4.6-115.3) 89 417.2 (6.0-2743.8) 4704.8 (-74.6-45630.7)
Urine glycine/creatinine 63 0.2 (0.0-2.1) 61 0.9 (0.0-4.6) 293.1 (-74.5-3225.6)
Urine betaine/creatinine 62 0.0 (0.0-0.5) 62 0.3 (0.0-1.1) 802.7 (-59.3-5991.0)

*Relative change between pre-chemotherapy (i.e., value before ifosfamide infusion) and 24 h after completion of chemotherapy cycle

eGFR, Estimated glomerular filtration rate (Schwartz 2009); TmP/GFR, Renal tubular maximum reabsorption rate of phosphate