Table 2.
Causal effects of modifiable lifestyle factors on impingement syndrome of shoulder using MR analyses
| Exposure | MR method | OR (95%CI) | Beta (SE) | P | P− het | P− pleio |
|---|---|---|---|---|---|---|
| Smoking initiation | MR Egger | 0.91 (0.50, 1.67) | -0.089 (0.31) | 0.77 | 0.0068 | |
| MR Egger intercept | 0.0048 (0.0059) | 0.41 | ||||
| Weighted median | 1.11 (0.90, 1.35) | 0.10 (0.10) | 0.33 | |||
| IVW | 1.17 (1.01, 1.35) | 0.16 (0.074) | 0.035 | 0.0069 | ||
| MR-PRESSO distortion test | NA | |||||
| Alcoholic drinks per week | MR Egger | 3.59 (1.00, 12.86) | 1.28 (0.65) | 0.052 | 0.0023 | |
| MR Egger intercept | -0.012 (0.0078) | 0.13 | ||||
| Weighted median | 1.97 (0.96, 4.02) | 0.68 (0.36) | 0.065 | |||
| IVW | 1.44 (0.85, 2.44) | 0.37 (0.27) | 0.17 | 0.0015 | ||
| MR-PRESSO distortion test | 0.80 | |||||
| Coffee consumption | MR Egger | 1.01 (1.00, 1.02) | 0.0094 (0.0057) | 0.12 | 0.95 | |
| MR Egger intercept | -0.014 (0.014) | 0.31 | ||||
| Weighted median | 1.01 (1.00, 1.01) | 0.0061 (0.0038) | 0.12 | |||
| IVW | 1.00 (1.00, 1.01) | 0.0042 (0.0030) | 0.15 | 0.93 | ||
| MR-PRESSO distortion test | NA | |||||
| Moderate-to-vigorous physical activity | MR Egger | 21.76 (0.20, 2428.16) | 1.08 (2.41) | 0.22 | 0.18 | |
| MR Egger intercept | -0.041 (0.035) | 0.27 | ||||
| Weighted median | 1.04 (0.36, 2.95) | 0.039 (0.53) | 0.87 | |||
| IVW | 1.42 (0.61, 3.28) | 0.35 (0.43) | 0.42 | 0.16 | ||
| MR-PRESSO distortion test | NA | |||||
| Sedentary behavior | MR Egger | 3.85 (0.093, 159.16) | 1.34 (1.90) | 0.55 | 0.79 | |
| MR Egger intercept | -0.063 (0.060) | 0.40 | ||||
| Weighted median | 0.54 (0.22, 1.35) | -0.61 (0.46) | 0.20 | |||
| IVW | 0.55 (0.25, 1.19) | -0.60 (0.39) | 0.13 | 0.67 | ||
| MR-PRESSO distortion test | NA | |||||
| Insomnia | MR Egger | 1.59 (0.76, 3.32) | 0.46 (0.38) | 0.22 | 0.0018 | |
| MR Egger intercept | 0.00093 (0.0071) | 0.90 | ||||
| Weighted median | 1.52 (1.16, 2.00) | 0.42 (0.14) | 0.0025 | |||
| IVW | 1.66 (1.38, 2.00) | 0.51 (0.10) | 8.86E-08 | 0.0021 | ||
| MR-PRESSO distortion test | 0.78 | |||||
| Sleep duration | MR Egger | 1.00 (0.97, 1.02) | -0.0043 (0.13) | 0.74 | 0.087 | |
| MR Egger intercept | 0.0059 (0.013) | 0.64 | ||||
| Weighted median | 1.00 (0.99, 1.01) | -0.0062 (0.045) | 0.56 | |||
| IVW | 1.00 (1.00, 1.01) | 0.0016 (0.0033) | 0.63 | 0.098 | ||
| MR-PRESSO distortion test | NA | |||||
| Short sleep duration | MR Egger | 1.59 (0.43, 5.90) | 0.46 (0.67) | 0.50 | 0.50 | |
| MR Egger intercept | -0.0013 (0.023) | 0.95 | ||||
| Weighted median | 1.41 (0.92, 2.16) | 0.34 (0.22) | 0.12 | |||
| IVW | 1.53 (1.14, 2.05) | 0.42 (0.15) | 0.0043 | 0.56 | ||
| MR-PRESSO distortion test | NA | |||||
| Time spent using computers | MR Egger | 0.56 (0.049, 6.50) | -0.58 (1.25) | 0.65 | 0.29 | |
| MR Egger intercept | 0.0047 (0.016) | 0.76 | ||||
| Weighted median | 1.08 (0.60, 1.95) | 0.074 (0.30) | 0.81 | |||
| IVW | 0.81 (0.53, 1.26) | -0.21 (0.22) | 0.35 | 0.31 | ||
| MR-PRESSO distortion test | NA | |||||
| Weekly usage of mobile phones in last 3 months | MR Egger | 6.71 (0.0045, 9908.00) | 1.90 (3.72) | 0.62 | 0.0031 | |
| MR Egger intercept | -0.0075 (0.075) | 0.92 | ||||
| Weighted median | 5.46 (1.88, 15.91) | 1.70 (0.55) | 0.00019 | |||
| IVW | 4.65 (1.59, 13.64) | 1.54 (0.55) | 0.0051 | 0.0055 | ||
| MR-PRESSO distortion test | 0.50 | |||||
| Job involving heavy manual or physical work | MR Egger | 0.12 (0.0031, 4.72) | -2.11 (1.87) | 0.27 | 0.54 | |
| MR Egger intercept | 0.058 (0.030) | 0.068 | ||||
| Weighted median | 4.25 (1.70, 10.67) | 1.44 (0.47) | 0.0033 | |||
| IVW | 4.24 (2.17, 8.26) | 1.44 (0.34) | 0.000022 | 0.37 | ||
| MR-PRESSO distortion test | NA |
MR: mendelian randomization; OR: odds ratio; 95%CI: 95% confidence interval; Beta was the estimated effect size; SE: standard error; P− het: P value for heterogeneity test; P− pleio: P value for pleiotropy test using MR-Egger regression analysis; IVW: inverse variance weighting; P < 0.05 was considered statistically significant