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. 2024 Mar 18;23:99. doi: 10.1186/s12933-024-02192-4

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Findings from the subgroup analyses. A Changes in BMI with simultaneous versus sequential combination therapy at the 6-month follow-up. B Changes in SBP with simultaneous versus sequential combination therapy at the 6-month follow-up. C Changes in HbA1c levels with simultaneous versus sequential combination therapy at the 6-month follow-up. D Changes in FPG levels with simultaneous versus sequential combination therapy at the 6-month follow-up. BMI body mass index, CI confidence interval, FPG fasting plasma glucose, GLP-1RA glucagon-like peptide-1 receptor agonist, HbA1c glycated hemoglobin, IV importance value, SBP systolic blood pressure, SD standard deviation, SGLT2i sodium–glucose transport protein 2 inhibitor, Seq. Combn. Tx sequential combination therapy, Simult. Combn. Tx simultaneous combination therapy

Fig. 4 — Findings from the subgroup analyses. A Changes in BMI with simultaneous versus sequential combination therapy at the 6-month follow-up. B Changes in SBP with simultaneous versus sequential combination therapy at the 6-month follow-up. C Changes in HbA1c levels with simultaneous versus sequential combination therapy at the 6-month follow-up. D Changes in FPG levels with simultaneous versus sequential combination therapy at the 6-month follow-up. BMI body mass index, CI confidence interval, FPG fasting plasma glucose, GLP-1RA glucagon-like peptide-1 receptor agonist, HbA1c glycated hemoglobin, IV importance value, SBP systolic blood pressure, SD standard deviation, SGLT2i sodium–glucose transport protein 2 inhibitor, Seq. Combn. Tx sequential combination therapy, Simult. Combn. Tx simultaneous combination therapy