Table 4.
Role and Mechanisms of lncRNAs in BC tamoxifen resistance.
| lncRNA | Role | Mechanism |
|---|---|---|
| SNHG6 (137) | Inducing | SNHG6 decrease tamoxifen sensitivity of BC cells by inhibiting miR-101and inducing EMT |
| LINP1 (138) | Inducing | LINP1 downregulates ER protein and attenuates estrogen response to trigger tamoxifen resistance |
| DSCAM-AS1 (139) | Inducing | DSCAM-AS1 promotes propagation of tamoxifen-resistant BC cells and inhibits apoptosis |
| HNF1A-AS1 (140) | Inducing | HNF1A-AS1 sponges miR-363 to promote SERTAD3 expression, stimulating tamoxifen resistance of BC cells |
| CCAT2 (141) | Inducing | CCAT2 sponges miR-145-5p, and activates PI3K/AKT/mTOR signaling pathway to promote tamoxifen resistance |
| BNAT1 (142) | Inducing | BNAT1 activates ERα signaling in tamoxifen resistant BC cells |
| BDNF-AS (143) | Inducing | BDNF-AS acts as scaffold of RNH1/TRIM21, abolishes RNH1-regulated mTOR mRNA decay to activate mTOR pathway |
| ATXN8OS (144) | Inducing | ATXN8OS activates VASP via sponge miR16-5p and promotes BC cell migration and metastasis |
| DC (145) | Inducing | DC promotes phosphorylation of STAT3 and upregulates Bcl-2 and Bcl-xL to reduce tamoxifen-induced apoptosis |
| LINC00894-002 (146) | Blocking | LINC00894-002 upregulates miR-200a-3p and miR-1b-1p, consequently inhibits TGF-β and oncogenic ZEB1 |
| Uc.57 (147) | Blocking | Uc.57 inhibits BCL11A and its downstream PI3K/AKT and MAPK pathways |
| ADAMTS9-AS2 (148) | Blocking | ADAMTS9-AS2 upregulates PTEN by sponging miRNA-130a-5p and improves BC cells’ sensitivity to tamoxifen |