Table 5.

Role and Mechanisms of lncRNAs in BC trastuzumab resistance.

lncRNA	Role	Mechanism
AGAP2-AS1 (151)	Inducing	AGAP2-AS1 upregulates CPT1 and induces FAO to cause resistance
SNHG7 (152)	Inducing	SNHG7 inhibits miR-186 to promote proliferation, apoptosis resistance, migration and EMT of BC cells
ATB (153)	Inducing	ATB sponges miR-200c, upregulates ZEB1 and ZNF-217 and thereby induces EMT to promote trastuzumab resistance
ZNF649-AS1 (154)	Inducing	ZNF649-AS1 binds to PTBP1 and promotes ATG5 transcription to induce autophagy and trastuzumab resistance
SNHG14 (155)	Inducing	SNHG14 promotes H3K27 acetylation and increases PABPC1, leading to activation of NRF2 pathways and BC cell survival
GAS5 (156)	Blocking	GAS5 downregulates miR-21, increases G2/M cell cycle arrest and DNA damage to increase BC cells radiosensitivity