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Effect of transient expression of p85/iSH2 on cell motility. A549 cells were transfected with p85/iSH2 or a control plasmid and examined 48 h posttransfection for cell migration on fibronectin-coated membrane filters (A), for adenovirus-mediated gene delivery (B), and for virus internalization (C). In parallel studies, A549 cells were treated with the MAP kinase inhibitor PD98059 prior to assaying cell functions.
