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. 2024 Mar 5;18:1286872. doi: 10.3389/fnbeh.2024.1286872

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Copyright © 2024 Adeniyi, Adeyelu, Shrestha, Liu and Lee.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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RNA sequencing of differentially expressed genes in the prefrontal cortex. (A) Volcano plot showing the numbers of upregulated and downregulated differentially expressed genes in SM, MS, and MM groups in comparison to control (SS). (B) Overlap between differentially upregulated and downregulated genes in each group. (C) Heatmaps showing clusters of differentially expressed genes in different groups. (D) Protein interaction network showing ADCY1, Akt3, and CAMk2a (in red) are hubs and highly differentially expressed during methamphetamine treatment.