Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2024 Mar 19;221(5):e20231359. doi: 10.1084/jem.20231359

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2024 Zhao et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).

PMC Copyright notice

Figure 5. — Intrinsic cellular properties and communication capabilities endow metastatic seeds with soil preselection. (A) GSEA shows higher expression of receptor and ligand genes in lung-metastatic lines (n = 2) compared with liver-metastatic lines (n = 2). ES, enrichment score. (B) Functional enrichment analysis of receptor and ligand genes in liver-metastatic and lung-metastatic lines. (C) The thickness of the lines represents the intensity of cellular communication between P1 lung-metastatic lines and P3 liver-metastatic lines with specific cell types in human lung tissue. (D) Lung-metastatic lines exhibited significant overexpression of ligand genes whose corresponding receptors were expressed on the cell surface of capillary ECs. (E) Comparison of ligand genes between CRC lung- and liver-metastatic tissues. P values were calculated using the R package limma. The y-axis represents the signal intensity after log2 RNA signal transformation. M.lung, lung metastases from CRC; M.liver, liver metastases from CRC. *, P < 0.05; **, P < 0.01; ****, P < 0.0001.