Fig. 3 |. Geneformer boosted predictions of chromatin dynamics with limited data.

a-b, ROC curve of Geneformer fine-tuned to distinguish bivalent vs. (a) non-methylated or (b) Lys4-only-methylated genes in 56 conserved loci from Bernstein et al. Cell 2006 using limited data (~15K ESCs), compared to alternative methods. c, ROC curve of Geneformer’s genome-wide predictions of bivalent vs. Lys4-only-methylated genes after fine-tuning on only 56 loci as in (b). d, ROC curve of Geneformer fine-tuned to distinguish long- vs. short-range TFs using limited data (~38K cells from iPSC to cardiomyocyte differentiation), compared to alternative methods. (Alternative methods described in Fig. 2.)