Table 2.

Mediating roles of vascular biomarkers with global cognition as outcome

Mediator	Path	T-score	P-value
Stiffness	WMH → global cognition	−3.36	0.0009
	CMC → global cognition	−2.10	0.021
WMH	µ → global cognition	2.44	0.001
	CMC → global cognition	−0.53	0.879
CMC	µ → global cognition	0.43	0.491
	WMH → global cognition	0.11	0.410

Both direct and indirect effects are assessed by controlling for age, sex and the rest of the covariables.