Extended Data Fig. 5 |. Soluble stimuli dominantly suppress pHEL signaling.

a. As in Main Fig. 6f, but with inclusion of anti-IgM 10 μg/ml as second stimulus following pHELD pre-treatment. Data are representative of 4 independent experiments. b. Data correspond to Main Fig. 6g but depict same samples with single cell resolution. c. As in Main Fig. 6g but with sHEL 1 μg/ml added at peak calcium response following pHEL stimulation. Data are representative of 3 independent experiments.