Table 1.
In vitro BNZ dissolution efficiency and stability of BNZ-MP stored at room temperature up to 36 months
| Sample | Dissolution efficiency (±s.d.) | (%) Drug content (±s.d.) | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Time (min) | Time (month) | |||||||||||||
| 10 | 15 | 20 | 30 | 45 | 60 | 90 | 120 | 0 | 6 | 9 | 12 | 24 | 36 | |
| BNZ-MP-RLa | 83.56**** (9.97) | 86.68**** (8.03) | 89.64**** (7.41) | 92.28**** (6.37) | 91.51**** (5.67) | 91.52*** (4.98) | 91.31** (5.28) | 92.73* (4.98) | 22.90 (0.55) | 22.88 (0.57) | 22.76 (0.48) | 22.92 (0.41) | 21.52 (0.96) | 21.86 (1.44) |
| BNZ-MP-RSb | 58.95*** (6.83) | 71.13*** (6.01) | 78.92*** (8.05) | 80.00**** (3.42) | 81.88*** (3.63) | 82.59** (3.05) | 83.59 (2.37) | 83.80 (2.01) | 23.09 (1.47) | 23.05 (0.40) | 22.00 (0.81) | 21.63 (0.29) | 21.53 (1.28) | 21.64 (0.83) |
| BNZc | 15.57 (2.61) | 22.82 (2.62) | 29.62 (3.89) | 38.59 (4.43) | 51.37 (4.11) | 60.36 (4.48) | 74.40 (3.58) | 81.79 (3.31) | – | – | – | – | – | – |
a
BNZ-MP-RL: microparticles of Eudragit® RL PO loaded with benznidazole.
b
BNZ-MP-RS: microparticles of Eudragit® RS PO loaded with benznidazole.
c
BNZ: raw benznidazole.
Difference is statistically significant with respect to BNZ: *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001.