Table 3.
Logistic proportional hazard regression analyses for elevated D-dimer.
| Variables | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| OR (95% CI) | p value | OR (95% CI) | p value | |
| Age | 1.073 (1.020-1.129) | 0.007 | 1.068 (0.991-1.150) | 0.084 |
| Gender (male) | 0.542 (0.227-1.294) | 0.168 | ||
| BMI (kg/m2) | 1.138 (0.930-1.394) | 0.210 | ||
| CHA2DS2-VASc score | 1.176 (0.830-1.665) | 0.362 | ||
| Hypertension | 3.873 (0.849-17.667) | 0.080 | 6.739 (0.727-62.444) | 0.093 |
| Diabetes mellitus | 1.021 (0.420-2.480) | 0.964 | ||
| Hyperlipidemia | 1.182 (0.387-3.612) | 0.769 | ||
| Stroke | 0.953 (0.385-2.362) | 0.917 | ||
| Anticoagulation protocols (rivaroxaban vs. dabigatran) | 3.632 (1.160-11.364) | 0.027 | 0.023 (0.245-4.270) | 0.975 |
| Closure size | 0.881 (0.689-1.127) | 0.313 | ||
| LVDD | 1.041 (0.969-1.118) | 0.271 | ||
| LVDS | 1.041 (0.963-1.125) | 0.310 | ||
| LVEF | 0.961 (0.905-1.019) | 0.184 | ||
| hs-CRP | 1.164 (1.053-1.287) | 0.003 | 1.154 (1.036-1.286) | 0.009 |
| Coagulation and platelet activation biomarkers | ||||
| TAT | ||||
| LA | 1.015 (0.993-1.037) | 0.178 | ||
| LAA | 1.007 (0.982-1.034) | 0.583 | ||
| Vein | 0.993 (0.962-1.026) | 0.677 | ||
| sP-selectin | ||||
| LA | 1.000 (1.000-1.001) | 0.038 | 1.001 (1.000-1.001) | 0.071 |
| LAA | 1.000 (1.000-1.001) | 0.277 | ||
| Vein | 1.000 (1.000-1.000) | 0.954 | ||
| vWF | ||||
| LA | 1.002 (0.998-1.005) | 0.397 | ||
| LAA | 1.001 (0.997-1.006) | 0.555 | ||
| Vein | 1.000 (0.997-1.004) | 0.933 | ||
| CD40L | ||||
| LA | 1.000 (0.997-1.003) | 0.928 | ||
| LAA | 1.002 (1.000-1.005) | 0.072 | 1.004 (1.000-1.007) | 0.049 |
| Vein | 1.002 (0.998-1.006) | 0.271 | ||
The hazard ratio (HR) and the 95% confidence interval (CI) were calculated using univariate Cox regression, and variables with a statistical significance of p < 0.10 were entered into the multivariate stepwise Cox proportional hazard regression model. BMI: body mass index; sCr: serum creatinine; RAASi: renin angiotensin aldosterone system inhibitor; LVDD; left ventricular end diastolic dimension; LVDS: left ventricular end systolic diameter; LVEF: left ventricular ejection fraction; hs-CRP: high-sensitivity C-reactive protein.