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. 2024 Jan 23;6(1):38–50. doi: 10.1016/j.jaccao.2023.11.008

Central Illustration.

Central Illustration

Mechanistic Implications of Relevant Candidate Genes in DOX-Induced Cardiotoxicity

The different mechanisms of cardiotoxicity after exposure to doxorubicin (DOX) are highlighted in colored boxes. AA = arachidonic acid; ABC = adenosine triphosphate–binding cassette; EET = epoxyeicosatrienoic acid; mRNA = messenger RNA; ROS = reactive oxygen species; SLC = solute carrier; SR = sarcoplasmic reticulum.