Table 1.

Mechanistic Implications of Genes Associated With DIC

Group	Gene	First Author (Year) Ref#	Mechanistic Implication
1	CAT	Rajic et al (2009)31	ROS generation/handling32
	CBR1	Armenian et al (2013)33	ROS generation/handling34
	CBR3	Visscher et al (2012),9 Armenian (2013)33	ROS generation/handling34
	ERBB2	Boekhout et al (2016)35	ROS generation/handling36
	GPX3	Visscher et al (2015)12	ROS generation/handling37
	GSTM1	Singh et al (2020)20	ROS generation/handling
	GSTP	Visscher et al (2012),9 Rossi et al (2009)38	ROS generation/handling39
	HAS3	Wang et al (2014)40	ROS generation/handling41
	NOS3	Krajinovic et al (2016)14	ROS generation/handling42
	PLCE1	Hildebrandt et al (2017)43	ROS generation/handling44
	RAC2	Armenian et al (2013),33 Rossi et al (2009)38	ROS generation/handling45
	SPG7	Visscher et al (2013)10	ROS generation/handling46
2	PRDM2	Wells et al (2017)5	DNA damage47
	MLH1	Krajinovic et al (2016)14	DNA damage48
	RARG	Aminkeng et al (2015)3	DNA damage3
3	HFE	Armenian et al (2013)33	Iron uptake and homeostasis49
4	SLC22A17	Visscher et al (2015)12	DOX uptake13
	SLC28A1	Visscher et al (2012)9	DOX uptake50
	SLC28A3	Visscher et al (2012),9 Visscher et al (2013)10	DOX uptake19
	ABCB4	Visscher et al (2012)9	DOX efflux51
	ABCC2	Aminkeng et al (2015)3	DOX efflux52
	ABCC5	Krajinovic et al (2016)14	DOX efflux14
	ABCC9	Visscher et al (2015)12	DOX efflux53
	ABCC10	Visscher et al (2015)12	DOX efflux53
5	CELF4	Wang et al (2016)6	Calcium handling54
	MYH7	Wasielewski et al (2014)55	Calcium handling56
6	CYP2J2	Visscher et al (2015)12	Cardiac electrical activity57
	RIN3	Aminkeng et al (2015)3	Cardiac electrical activity58
	ZFN521	Aminkeng et al (2015)3	Cardiac electrical activity59

DIC = doxorubicin-induced cardiotoxicity; DOX = doxorubicin; ROS = reactive oxygen species.