Fig. 6.

CLEC2D promotes tumor growth and immune infiltration of ccRCC cells in vivo. CLEC2D shRNA and empty vector were stably transfected into 786-O cells, which were then implanted in nude mice to form tumors. Representative images and tumor growth curves are shown (A). Immunohistochemistry was performed to detect the expression of CLEC2D in tumor tissues from the indicated groups (B). (C, D). Proportions of intratumoral CD8⁺ T cells (C) and INF-γ. (D) produced was quantified from tumor tissues in shControl and shCLEC2D mice.