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. 2024 Jan 24;4(3):336–349. doi: 10.1038/s43587-023-00560-5

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 7 — a,b, Percentage of CD4⁺ or CD8⁺ cells among CD45.1⁺ T cells from the spleen (a) or liver (b) of 4-month-old or 20-month-old mice 20 days after cell infusion (n = 3 mice per age group for untransduced T cells [UT] and for h.19-m.28z; n = 4 for m.uPAR-m.28z). c,d, Percentage of CD45.1⁺ T cells expressing differentiation markers CD62L and CD44 in the spleen (c) or liver (d) of 4-month-old or 20-month-old mice 20 days after cell infusion (sample sizes as in a). e,f, Percentage of CD4⁺ or CD8⁺ cells among CD45.1⁺ T cells in the spleen (e) or liver (f) of 15-month-old mice 12 months after cell infusion (n = 3 mice per group). g,h, Percentage of CD45.1⁺ T cells expressing differentiation markers CD62L and CD44 on CD45.1⁺ T cells in the spleen (g) or liver (h) of 15-month-old mice 12 months after cell infusion (n = 3 mice per group). i, Time to exhaustion in exercise capacity testing 12 months after cell infusion (n = 8 for untransduced T cells; n = 6 for h.19-m.28z; n = 12 for m.uPAR-m.28z). j, Maximum speed (m/min) in capacity testing 12 months after cell infusion (sample sizes as in i). k-m, Quantification of SA-β-Gal–positive cells 12 months after cell infusion in (k) adipose tissue (n = 6 for UT; n = 5 for h.19-m.28z; n = 6 for m.uPAR-m.28z); (l) liver (n = 6 for UT; n = 5 for h.19-m.28z; n = 5 for m.uPAR-m.28z) and (m) pancreas (n = 6 for UT; n = 5 for h.19-m.28z; n = 6 for m.uPAR-m.28z). n-p, Quantification of uPAR-positive cells in (n) adipose tissue, (o) liver and (p) pancreas 12 months after cell infusion (n = 3 per group). Results of 1 independent experiment (a-h, n-p) or 2 independent experiments (i-m). Data are mean ± s.e.m.; p values from two-tailed unpaired Student’s t-test (a-h, k-p) or two-tailed Mann Whitney test (i,j).

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