Fig. 2. Upregulation of uPAR and senescence signatures in aged human pancreas.

scRNA-seq data of human pancreas of different ages from ref. ²⁶ were analyzed. a, UMAP visualization of Plaur expression across pancreas cell types in young humans (0–6 years old) and old humans (50–76 years old). b, UMAP visualization of senescence signature expression¹⁷ across pancreas cell types in young humans (0–6 years old) and old humans (50–76 years old). c, Quantification of the proportion of uPAR-positive and uPAR-negative cells by cell type and age. d, Quantification of the proportion of cells expressing senescence signature¹⁷ or not expressing senescence signature¹⁷ by cell type and age.