TABLE 4.
Inoculation of suckling mice and 5-week-old mice
| Virus | Suckling mice (intracranial inoculation)
|
5-week-old mice (subcutaneous inoculation)
|
||||
|---|---|---|---|---|---|---|
| LD50 (PFU) | Mean survival time (days) aftera:
|
LD50 (PFU) | ID50 (PFU) | LD50/ID50 | ||
| 1 PFUb | 0.1 PFUb | |||||
| Neudoerfl | 10−1.7 | 7.2 (±1.5) | 8.2 (±1.5) | 100.9 | 10−0.2 | 101.1 |
| R-Nd/3′Δ10795 | 10−2.5 | 7.7 (±1.4) | 8.5 (±0.9) | 101.0 | 10−0.4 | 101.4 |
| R-Nd/3′Δ10826 | 10−2.3 | 11.0 (±0.8) | 10.7 (±1.7) | 104.9 | 100.4 | 104.5 |
| R-Nd/3′Δ10847 | 10−1.9 | 11.1 (±0.9) | 11.4 (±0.9) | 105.0 | 101.0 | 104.0 |
| R-Nd/3′Δ10870 | 10−2.1 | 12.5 (±2.5) | 11.9 (±1.5) | >105.0 | 102.4 | >102.6 |
| R-Nd/3′Δ10919 | 10−2.4 | 12.6 (±0.6) | 11.5 (±0.5) | >105.0 | 100.5 | >104.5 |
a
In parentheses is the standard error of the mean, calculated as ς =
 |
b
Inoculation dose/mouse. For each virus and dose, litters of 7 to 12 mice were inoculated. No mice survived at these inoculation doses.