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. 2024 Mar 19;81(1):146. doi: 10.1007/s00018-024-05128-z

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 9 — Histological characterization of Lyve1⁺ and MHCII^hi macrophages. a Representative image of Lyve1 and CD206 colocalization (white dotted box = the area magnified in the right-most image on each row). b Representative image of Lyve1 and CD68 colocalization. c Quantification of Lyve1⁺ percent area from co-staining with CD206 shows a significant increase in the percent area of Lyve1 in 21-week-DB mice as compared to all other groups. Pearson’s correlation for Lyve1 with d CD206 and e CD68 revealed a positive correlation between Lyve1 and CD206 and a significant increase in the correlation between Lyve1 and CD68 in the 12- and 21-week-DB mice as compared to 12-week-WT mice. f Representative image of MHCII and CD206 colocalization. g Representative image of MHCII and CD68 colocalization. h Quantification of MHCII percent area from co-staining with CD206 shows no significant differences between groups. Pearson’s correlations for MHCII with both i CD206 and j CD68 revealed a negative correlation between MHCII and CD206 and between MHCII and CD68, although there was a significantly higher colocalization between MHCII and CD68 within 21-week-WT mice as compared to 12-week-DB mice. *p < 0.05: **p < 0.01. Data are mean ± SD (n = 4–6)