Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2024 Mar 6;15:1353402. doi: 10.3389/fimmu.2024.1353402

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2024 Stemmer, Zahavi, Kellerman, Sinberger, Shrem and Salmon‐Divon

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

IPA Functional analysis. (A-C) Top five activated (orange) and inhibited (blue) canonical pathways based on absolute IPA’s activation z-score > 2 for the following comparisons: (A) UC vs non-IBD control, (B) CD vs non-IBD control, (C) IBD vs non-IBD control. Negative z score value implies an overall pathway's inhibition and a positive z-score value suggests an overall pathway's activation. All pathways had -log (B-H p-value) > 1.3 meaning FDR less than 0.05. (D) Hierarchical clustering of upstream regulators’ activation z score across all comparisons.