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. 2024 Mar 6;15:1353402. doi: 10.3389/fimmu.2024.1353402

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Copyright © 2024 Stemmer, Zahavi, Kellerman, Sinberger, Shrem and Salmon‐Divon

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Distribution of the normalized expression of selected genes across UC, CD and non-IBD control samples in (A) Mega-analysis dataset: CD (n= 183), UC (n= 386) and control group (n=128). P-values were calculated using two-way analysis of variance (ANOVA). (B) GSE193677 validation dataset: The dataset includes inflamed samples from CD (n=60, ileum) and UC (n=60, rectum), along with non-IBD control samples from both the ileum (n=60) and rectum (n=60). Statistical significance was assessed using Student’s t-test. *p < 0.05, ****p < 0.0001 indicate the significance levels.