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. 2024 Jan;45(1):62–67. [Article in Chinese] doi: 10.3760/cma.j.cn121090-20230928-00147

表3. mNGS与常规方法、RQ-PCR对耶氏肺孢子菌肺炎(PJP)患者的诊断效能比较.

方法 敏感性(95% CI 特异性(95% CI PPV(95% CI NPV(95% CI
mNGS 100.0%(69.9%~100.0%) 98.8%(92.8%~99.9%) 92.3%(62.1%~99.6%) 100.0%(94.6%~100.0%)
常规方法 8.3%(0.4%~40.2%)a 100.0%(94.7%~100.0%)b 100.0%(5.5%~100.0%)b 88.7%(80.2%~94.5%)a
RQ-PCR 91.6%(59.8%~99.6%)b 100.0%(94.7%~100.0%)b 100.0%(67.9%~100.0%)b 98.9%(92.9%~99.9%)b

注 mNGS:宏基因组二代测序;RQ-PCR:实时定量-聚合酶链反应;PPV:阳性预测值;NPV:阴性预测值。与mNGS比较,aP<0.05;与mNGS比较,bP>0.05